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They may also slow the progression of diabetes-related nephropathy, making them valuable in comprehensive diabetes management (10)
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This reduces the risk of experiencing side effects
Safety Profile The most common adverse events documented across retatrutide results data were gastrointestinal in nature, with incidence increasing at higher doses: Nausea: 6-31% (dose-dependent), primarily during escalation periods Diarrhea: 6-25%, generally mild to moderate Vomiting: 0-16%, occurring mainly in the first weeks of each dose increase Decreased appetite: 3-19%, which contributed to the weight reduction effect Constipation: 3-12%, consistent with GLP-1 receptor-mediated gastric slowing Serious adverse events were rare across all cohorts
Sodiumglucose cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects in large kidney-dedicated outcome trials [4,5,6], and dedicated kidney outcome trials on glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1ras) are awaited
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