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Constant, non-pulsatile GH rise (as occurs with synthetic GH use) can lead to receptor desensitization, where target tissues become less responsive to growth hormone over time

Indeed, it was demonstrated that heterodimerization of 1-cysPrx with GSH-saturated GSTP results in S -glutathionylation of the oxidized cysteine in 1-cysPrx followed by subsequent spontaneous reduction of the mixed disulfide and restoration of enzymatic activity (Manevich et al., 2004)

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Expression and purification of Fab7F38 ExpiCHO-S cells (mouse, Chinese hamster ovary) were cultured in serum free ExpiCHO Expression Medium (Gibco)