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An in vivo mouse study revealed that selenium supplementation induced significant alterations in 31 metabolites in the brains of conventional mice, whereas only 26 metabolites changed in microbiota-depleted mice 79 .In this study, untargeted metabolomics analysis revealed that MP intervention significantly remodeled the gut metabolic state of fatigued mice

In all these studies the average intracellular GSH and GSSG concentrations were assessed without discriminating between the ratio of GSH to GSSG in the pre-membrane pool and that in the cytosolic core