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The current addiction studies are phase 2 and sponsored by universities, hospitals, or the NIH
Pathogen exposure may trigger trained immunity in sarcoidosis, peripheral blood mononuclear cells (PBMCs) from patients produce higher TNF and IL-6 levels upon bacterial or fungal stimulation than those from healthy controls and show abnormal expression of pathogen-sensing PRRs (44)
Cells 10:e1831 Muller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L, Czajkowski MT, Welke RW, Zhang S, Nguyen V et al (2020) Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions
