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Some research protocols have explored doses up to 4.5 mg weekly, which showed slightly greater efficacy in the phase 2 dose-finding trial but also increased side effect burden
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GLP-1RA Cardiovascular Disease Outcomes Starting in 2008, the FDA began requiring all medications indicated for treatment of type 2 diabetes to evaluate cardiovascular risk reduction [45]
In clinical weight loss studies, tirzepatide has generally produced greater average weight loss than semaglutide at studied therapeutic doses
The tapering protocol: step by step If you and your provider decide that discontinuation is the goal, doing it right dramatically improves your chances of maintaining results
