With regard to catalytic mechanism, all the seleno-GPxs share the common pathway which starts with the binding of hydroperoxides and GSH at the catalytic and thiol binding motifs, respectively [8, 11,12,13,14,15,16,17,18]
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This result identifies an unexpected B cell-specific function of GSH in the regulation of the TCA cycle and the ETC
Peer review Peer review information Nature Catalysis thanks Mattheos Koffas, Bengt Mannervik, Boas Pucker, Dingguo Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
The most commonly reported side effects include: Mild injection site pain, redness, or swelling Nausea or gastrointestinal discomfort Fishy body odor due to trimethylamine accumulation at higher doses Increased heart rate in sensitive individuals Allergic reactions rash, itching, swelling are rare but possible in patients with hypersensitivity to L-Carnitine
