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Principle of Accumulation When a drug is administered repeatedly at a fixed dosing interval () that is shorter than the time required for its complete elimination (approximately 4-5 half-lives), the drug will accumulate in the body

However, it may occur indirectly through mechanisms such as dehydration from gastrointestinal side effects, blood pressure changes, or hypoglycemia, particularly in patients taking insulin or sulfonylureas

Common side effects include nausea, constipation, and other digestive issues

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Published April 12, 2024