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When GPX4 is inhibited or depleted, lipid peroxidation spirals out of control, leading to cell death ( - , which imports cystine for glutathione (GSH) synthesis, also plays a crucial role
4 integrates extracellular stress and growth cues to regulate cell-cycle progression, apoptosis, and differentiation, and frequently cooperates with NF-B signaling to promote cancer cell survival and metastasis
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