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Contrary, while RES showed significant protection to the groups receiving 20 and 40 mg/kg, its efficacy was surprisingly lower when compared to mesna (Keles et al., 2014)

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In skin specifically, GHK-Cu has been extensively studied for its ability to increase collagen and elastin production, improve skin thickness and elasticity, reduce fine lines and wrinkles, improve skin firmness, reduce photodamage, reduce hyperpigmentation, and accelerate wound healing