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24 NakagawaT.MiyajiT.YurimotoH.SakaiY.KatoN.TomizukaN
Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models
doi: 10.21315/tlsr2016.27.2.6 548 De SimoneC
Meta-analyses and head-to-head clinical trials consistently show that GLP-1 receptor agonists outperform other diabetes treatments in reducing HbA1c and body weight
Similar content being viewed by others This article describes research in our and other laboratories on mitochondrial metabolism of acetyl-L-carnitine (LAC) that has led to the discovery of novel epigenetic mechanisms for the rapid regulation of brain plasticity in multiple rodent models and then has prompted us to uncover a role for this proposed mitochondrial signaling pathway of epigenetic function as a therapeutic target for clinical phenotypes of depression linked to childhood trauma, and implications for Alzheimers disease (Fig
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