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Moreover, L-carnitine mitigates post-ischemic myocardial injury primarily by counteracting the toxic impact of increased free fatty acid concentration and promoting more efficient carbohydrates metabolism (Ferrari et al

In the past, nesidioblastosis was synonymous with congenital hyperinsulinemia

There may be a role for microdosing in a few scenarios: When side-effects are not manageable: when side-effects are intolerable for patients, even on the lowest introductory dose, there may be a role for individualised approaches

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Inclusion criteria This review considered peer-reviewed studies of L-carnitine supplementation in subjects with coronary artery disease across predefined designs, each with a distinct role, including preclinical evidence such as animal studies which provided mechanistic evidence and insights on emerging pathways, as well as clinical evidence such as case reports, cross-sectional studies, observational studies, retrospective analyses, randomized controlled trials, systematic review and meta-analyses which provided primary evidence as well as quantitative analysis of clinical endpoints