retatrutide phase 3 results october 2025 Eli Lilly's shows promising weight loss in trial Retatrutide Phase 3 Updates: Significant

We applied quality control filters to people with weight less than 36 kg or greater than 181 kg, height less than 1.39 m or greater than 2.06 m, BMI less than 14 kg m 2 or greater than 70 kg m 2 , or age less than 18 years

however, changes in health behavior alone are usually unsustainable or insufficient, necessitating pharmacological therapy

Circulating GLP-1 from diet and lifestyle has a half-life of 1-2 minutes before being inactivated in our bodies (Mozafariun et al 2025

N Engl J Med (1961) 264:2269

But for those of us who specialize in metabolic psychiatry, who see patients with both obesity and mental health conditions, who understand the bidirectional relationships between these systems, GLP-1 medications are a valuable tool we should have available