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Additionally, the activation of neuroinflammatory agents and the increase of free radicals, such as nitric oxide (NO), which in turn induces further inflammatory responses, occur in patients with depression (6)

However, the trial's low event rate and reliance on serum creatinine to assess eGFR, which may be influenced by muscle mass changes, limit the robustness of its conclusions

Mechanistic case, trial data, and the open question

Given the connection between DS and the development of AD, G biloba is an important line of therapy when treating DS