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Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class
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Although it has been hypothesized that fluoxetine may interfere with spermatogenesis by affecting androgen levels, the concentrations of gonadotropins such as FSH and LH levels were not quantified in the study, and the underlying mechanism of action could not be directly confirmed
But even with this slow dose escalation, some people still find that the doses of traditional medicines are too high, resulting in uncomfortable side effects
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