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For aging populations, MDD presents an even greater concern, as it significantly raises the risk of Alzheimers disease, dementia, frailty, and reduced health span, underlining its multifaceted burden on both mental and physical health in older adults [491,492,493]

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Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis ( in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

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