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Int J Clin Pharmacol Res 1992;12:299-304

Results from a case series identified a potential association between JAMA Ophthalmology

None of the two studied TYMS polymorphisms resulted an independent maternal risk factor for a DS birth, but the combined MTHFR 1298AC/ TYMS 28-bp 2R/2R genotype resulted in decreased maternal risk (Copped et al., 2009)

Recent regulatory reviews by the MHRA and European Medicines Agency have assessed reports of psychiatric adverse events with GLP-1 receptor agonists, but no causal link has been established

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