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Improved blood sugar control and reduced body weight can lead to long-term health benefits

Abstract For over 100 years, clinicians and scientists have been unravelling the consequences of the A to T substitution in the -globin gene that produces haemoglobin S, which leads to the systemic manifestations of sickle cell disease (SCD), including vaso-occlusion, anaemia, haemolysis, organ injury and pain

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86.4% of participants lost 5% of body weight

The article explains that during weeks one to four of initiation or a dose increase, appetite suppression can outpace the adjustment in caloric intake while the body shifts which fuel it burns, producing transient fatigue or reduced motivation