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Exclusion criteria encompassed patients with scheduled orthopedic surgery due to walking limitations, peripheral revascularization within the last 180 days, recent acute myocardial infarction (AMI) or stroke, hospitalization for angina or transient ischemic attack (TIA) in the last 180 days, and renal function below 30 mL/min/1.73 m

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These effects are typically dose-dependent and tend to be most pronounced during the initial weeks of treatment or following dose escalation

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