So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets
For optimal results, apply daily at night time while avoiding sun exposure
iScience 26:105717 Kriston L, von Wolff A, Westphal A, Holzel LP, Harter M (2014) Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis
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10.4161/auto.1.1.1513 Autophagy 107 SadasivanS.DunnW