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Neochrysosporazines: precursor-directed biosynthesis defines a marine-derived fungal natural product P-glycoprotein inhibitory pharmacophore

2012;590(Pt 18):4585602

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Some metals inhibit the glutathione S-transferase from Van Lake fish gills

However, during a severe viral infection or prolonged periods of chronic inflammation, this vital defense system can become overwhelmed and depleted