GLP-1RAs provide a comprehensive defense against liver damage by exhibiting anti-inflammatory effects and promoting metabolic changes
RNA-Seq data is available online in GEO accession GSE195998
Although the actual mechanisms of MTX-induced liver and kidney damage are unknown, one of the hypotheses is the breakdown in cellular antioxidant defences, which increases the production of reactive oxygen species and nitrogen species, inhibits cytosolic NADP-dependent dehydrogenase and NADP malic enzyme, lowers glutathione (GSH), superoxide dismutase (SOD) and catalase levels and reduces the effectiveness of the antioxidant defence system protecting the cell against reactive oxygen species (Reference Savran, Cicek and Doguc7)
Here are some tips for effective monitoring: Check Your Skin Daily: Look at your skin every day, especially around the injection site
Since the stomach empties more slowly on GLP-1 meds, patients who continue to eat two or three times a day often overload their gutand get the predictable nausea, bloating, and constipation that can come with that