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Some chemotherapy drugs or antiretroviral medications (for HIV) that suppress bone marrow might also blunt the effectiveness of B therapy

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Conditions that shorten red cell lifespan such as haemolytic anaemia or acute blood loss mean cells spend less time in circulation and accumulate less glycated haemoglobin, producing a spuriously low HbA1c even when blood glucose is elevated

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They also consider the patients health and any special conditions