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(16) Hydrate and add electrolytes to reduce the risk of constipation, dizziness, and low energy as GLP-1s reduce appetite and fluid intake (8), especially important in midlife when dehydration worsens (17). Eat Nutrient-Dense Meals Build balanced meals by focusing on filling your plate with lean protein, colorful fruits and veggies, whole grains, and healthy fats

While the G-site is more hydrophilic in nature compared to the H-site, the extent of hydrophobicity of the H-site varies across GST classes and amongst individual GSTs [77, 78, 91]

Bowel changes become more predictable : Constipation is common, especially if fiber and fluids are low

Note that GLP-1 receptor agonists like Rybelsus have a low risk of causing hypoglycaemia when used alone

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