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This small molecule is a determining element of the complex detoxifying, immune, antioxidant and even anti-inflammatory system of the human body

For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145

This timing aligns with natural growth hormone release patterns, which peak during early sleep phases

10.1016/j.bcp.2025.117301 71 StefanovskiD.VajraveluM

Neurochem Res 16: 10991111