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doi: 10.1038/cdd.2015.158 41 GaoMMonianPPanQZhangWXiangJJiangX
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Recent progress in non-native nucleic acid modifications
7 (8), e42454 (2012)
Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation
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