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Some people use sublingual delivery (powder held under the tongue briefly before swallowing) but there's no strong evidence this meaningfully improves bioavailability for this compound class

Sakakeeny et al., Plasma Pyridoxal-5-Phosphate Is Inversely Associated with Systemic Markers of Inflammation in a Population of U.S

What that looks like in practice: some people notice shifts in energy and how their body composition responds before the scale moves much, since the goal is metabolic, not just water weight