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One study in mice that compared GHK to GKH-Cu to copper alone noted that GHK-Cu was more effective than GHK alone in terms of antioxidant effect, and copper alone produced no benefit

When endothelial cells release nitric oxide, nearby smooth muscle cells in the blood vessel wall respond by relaxing

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Side Effects Common side effects Nausea Vomiting Diarrhea Stomach pain Loss of appetite Serious but less common side effects Risk of pancreatitis Gallbladder issues (gallstones, inflammation) Kidney problems (from dehydration due to vomiting/diarrhea) Potential increased risk of thyroid C-cell tumors (based on animal studies) Patients should report severe or unusual symptoms to their healthcare provider immediately