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Many patients default to increasing cardio when the scale stalls, which can actually worsen a plateau by accelerating muscle breakdown and increasing cortisol

Stools may become infrequent and harder to pass

PMID: 39448200

IGF-1 availability is tightly regulated by the so-called insulin- like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF- 1R) [7]