Hellstrm, Uppsala University, Sweden I
Using the semaglutide salt has a greater potential for drug instability and variability which can increase the risk of adverse effects or therapeutic failure
In a 2018 guidance, FDA explained that it would consider a compounded drug to be essentially a copy of a commercially available drug if it has (i) the same API, (ii) the same or similar dosage, and (iii) the same route of administration, unless a prescriber determines that there is a change, made for an identified individual patient, which produces, for that patient, a significant difference from the commercially available drug product. The guidance also explains that, if a change is made for an identified patient, the prescriber should document the determination on the prescription, and the notations should be specific
Victoza (Liraglutide) Approved in 2010, Victoza was one of the earliest daily GLP-1 receptor agonists
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