It also serves as a required substrate for two important families of enzymes: the sirtuins, which help regulate healthy cellular aging, and the PARPs, which help repair damaged DNA
Pharma is innovating to hit even more targets The latest article I saw about the work being done in this class is a study in mice looking at a quintuple agonist (5 different targets!) I almost never write about mice studies because of how preliminary they are and how unlikely a finding in mice is to ever translate into anything useful in humans, but because of the success weve already seen of this drug class as well as the way that hitting more pathways seems to increase efficacy, I thought this was research worth highlighting
Yes, tirzepatide causes modest increases in resting heart rate, typically 24 beats per minute based on clinical trial data
Konerman MA, Jones JC, Harrison SA (2018) Pharmacotherapy for NASH: current and emerging
Low ferritin levels may indicate an iron deficiency