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individuals with pre-existing retinopathy should be aware of this risk [28] [29] Pregnancy and breastfeeding incretin-based therapies should be avoided during pregnancy and breastfeeding unless within a supervised clinical trial, as safety data in these populations are absent Delayed gastric emptying a class effect of GLP-1 receptor agonists can reduce the absorption rate of concomitant oral medicines

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Oxidative stress can also trigger premature neutrophil apoptosis or, conversely, NETosis (expulsion of nuclear chromatin webs), both of which can worsen outcomes NETs, for instance, have been implicated in postoperative organ failure like TRALI (transfusion-related lung injury) and microthrombosis (63)

Vitamin E has been considered an anti-inflammatory agent in the skin, as several studies have supported its prevention of inflammatory damage after UV exposure

Mitochondria are an important source of ROS in most cells