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In other cases, an immune reaction can occur, where histamine is released into the system producing rashes, itchy and watery eyes, hives, swelling, and a runny nose

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10.1007/s10038-007-0202-x Summary Keywords folate, polymorphisms, Down syndrome, congenital heart defects, DNA methylation, epigenetics, MTHFR, folic acid supplementation Citation Copped F (2015) The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects

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