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GLP-1s represent a powerful tool in the treatment of obesity, but their potential is best realized when embedded in a robust, personalized plan that prioritizes nutrition, movement, and behavioral health, the group concluded

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Retatrutide Phase 2 Obesity Trial: Efficacy and Safety at 48 Weeks New England Journal of Medicine Phase 2 trial in 338 adults with obesity showed retatrutide 12 mg produced 24.2% body weight loss at 48 weeks the highest reported for any anti-obesity pharmacotherapy with manageable GI side effects

F., Myung, S

The key is hydration, gradual escalation, and regular check-ins