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Only eight of the studies were with the new GLP-1 medications (semaglutide and tirzepatide)

GNC offers HMB, a metabolite of the amino acid leucine with many human clinical studies to support its use, which helps users maintain muscle and creatine can improve the effectiveness of strength training for lean muscle building and maintenance

It is worth noting that many clinical trials of GLP-1 agonists excluded people with significant psychiatric illness, which may limit our understanding of effects in these populations

In more severe cases, surgery followed by months of physiotherapy may represent the most appropriate course of treatment