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Nevertheless, if we compare the internal states corresponding to Nrf2Keap1 complexes (Fig 3D), the dissociation model predicts an immediate decrease in the complex upon exposure to DEM followed by a sharp increase in complex formation, while the hinge-latch model predicts a prolonged increase in the complex that starts immediately upon oxidative stress

Your doctor will weigh the benefits and any potential risks before prescribing

Further dose escalation occurs in 2.5 mg increments at minimum four-week intervals up to a maximum of 15 mg weekly

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Huang HH, Huang HH, et al