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Victoria Sandler, MD, clinical assistant professor at University of Chicago Pritzker School of Medicine and clinical endocrinologist at Endeavor Health

Metabolic Safety: IGF-1 and Glucose Effects One of the most clinically significant safety findings relates to AOD-9604s metabolic profile, particularly its lack of effects on insulin-like growth factor-1 (IGF-1) and glucose metabolism

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27 Both drug classes also improve lipid profiles: GLP-1 RAs reduce total cholesterol by 10% to 15% and low density lipoprotein (LDL) cholesterol by 5% to 10%, 28 while SGLT2 inhibitors improve total cholesterol by 4% to 7% and LDL cholesterol by 3% to 5%

Elective Surgery High-risk elective cases joint arthroplasty, major abdominal surgery require tighter protocols