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Two options that often come up are Ozempic (semaglutide) and compounded semaglutide

Large-scale, randomized controlled trials with robust stratification of HFpEF phenotypes are needed to confirm the efficacy and safety of GLP-1RAs in this population

The results of GLP-1 are not immediate but they can be dramatic

62.9% of patients achieved more than 20% weight loss compared to 1.3% on lifestyle changes alone

Wegovy GLP-1 receptor agonist only Average weight loss of approximately 1315% in clinical trials In head-to-head comparison, semaglutide achieved 13.7% mean weight loss at 72 weeks Often better tolerated for some individuals Zepbound Dual GIP and GLP-1 receptor agonist Average weight loss of 1521% , depending on dose 5 mg: ~15% 10 mg: ~19.5% 15 mg: ~21% In head-to-head comparison, tirzepatide achieved 20.2% mean weight loss at 72 weeks This does not mean Zepbound is universally superior