At full doses, some studies found that these medications may influence aging at both a cellular and systemic level by improving metabolic efficiency, reducing inflammation and shielding the body from the biological stressors that accelerate age-related decline
[6] [7] Dehydration and acute kidney injury (AKI): Significant gastrointestinal fluid losses (vomiting, diarrhoea) can lead to dehydration and secondary AKI, particularly in individuals taking diuretics or other nephrotoxic medicines
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Studying these pathways together allows researchers to investigate how multi-receptor agonism may redistribute metabolic energy flux across tissues [5]