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The targeted application and localized action minimize this risk
Methadone is used for opioid detoxification, opioid withdrawal therapy, and chronic pain management in certain populations
Interestingly, differences in prooxidative parameters were more profound in acute coronary syndrome patients compared with coronary artery disease patients indicating that the acute form of coronary artery disease is more susceptible to oxidative damage, suggesting that use of antioxidant therapy may be warranted to reduce oxidative stress in this disorder (154)
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