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Research-design considerations Designs using Retatrutide benefit from accounting for its extended half-life in study time-courses, allowing multi-week durations for steady state, including endpoints relevant to all three receptor systems, and for comparative work including single- or dual-agonist reference compounds

J., Yamamoto, S., Willoughby, D

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Subsequently, the milk/upper fraction was mixed with methanol and centrifuged to collect supernatant