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The following is a review of the preclinical and clinical studies examining the role of GLP-1R agonists on the vascular endothelium and HFpEF: Data from preclinical studies In a study on non-diabetic mice models with arterial hypertension (simulating preconditions for HFpEF), Liraglutide treatment improved blood pressure and cardiac hypertrophy in angiotensin II-induced arterial hypertension independent of glucose/insulin modulation leading to the reversal of cardiac hypertrophy

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Nat Rev Cardiol 20(7):475494 Yuen MMA (2023) Health complications of obesity: 224 obesity-associated comorbidities from a mechanistic perspective

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Understanding the difference between a 95% preclinical GLP-1 increase and what actually happens in the human body is exactly the kind of distinction that matters for real-world results