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Under physiological conditions, GLP- 1 is rapidly degraded by dipeptidyl peptidase-4 (DPP- 4) after it is released ( 3 Discovery of GLP-1 In 1923, Charles Kimball and John Murlin, in an attempt to purify commercial insulin, precipitated a pancreatic fraction that had a hyperglycemic effect ( Figure 1 The proglucagon precursor ( Figure 1 4 GLP-1 receptor The GLP-1 receptor is a member of the secretin subfamily (B1) of G-protein coupled receptors (GPCRs)

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S Afr J Bot 141:466473 Azlan UK, Khairul Annuar NA, Mediani A, Aizat WM, Damanhuri HA, Tong X et al (2023) An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera

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Wang X, Chang X, Zhan H, Zhang Q, Li C, Gao Q, Yang M, Luo Z, Li S, Sun Y (2020a) Curcumin and Baicalin ameliorate ethanol-induced liver oxidative damage via the Nrf2/HO-1 pathway