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Both drugs have independently been linked to increased pressure in the brain (intracranial hypertension), and combining them multiplies that risk
The pathology of OA is primarily characterized by cartilage degradation, synovial inflammation, osteophyte formation, and subchondral bone sclerosis 6,7
Based on these results all further permeability assays were made on inserts with 0.4 m pore size membranes
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