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For hair applications specifically, longer cycles of 12-16 weeks may be appropriate given the slow nature of hair regrowth, followed by 4-6 week breaks

It upregulates VEGF (vascular endothelial growth factor), promoting angiogenesis in damaged synovial tissue and cartilage

It is generally recommended to pause use during these periods

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While it appears to have a gentler profile than traditional hypnotics, the long-term effects of exogenous administration, its exact metabolic fate, and potential for interaction with complex neuroendocrine disorders remain unknown outside of controlled research settings