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Peripheral vs Central Action AOD-9604 functions exclusively through peripheral mechanisms in adipose tissue rather than through central nervous system pathways that regulate appetite

Kothari SS et al

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Furthermore, like most reconstitution solution vs bacteriostatic water, the solution is hypotonic and, therefore, it cannot be injected on its own due to the high risk of hemolysis

In summary, the reasons a GP surgery may refuse an early B12 injection are often rooted in a strict interpretation of established, but imperfect, guidelines, a misunderstanding of the actual science of B12 storage and metabolism, and a desire to maintain administrative consistency