Treatment of Iron Deficiency Anemia in CKD and End-Stage Kidney Disease
3.2 MAPK and NF-B pathway Mitogen-activated protein kinase (MAPK) pathway was also involved in the signaling of GLP-1R (5659)
Earlier observational studies had suggested GLP-1 drugs might help prevent cancer, but those studies were based on existing patient data, not controlled trials, and may have included healthier patients with better access to care
TL;DR: In a large sample of US Veterans, GLP-1 drugs were associated with reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimers disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions, but increased risk of gastrointestinal issues, hypotension (low blood pressure), and some kidney-related conditions
Purging (all congestion surfacing at once) is common