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3.4 Tirzepatide effects: adverse effects of tirzepatide Gastrointestinal adverse effects of tirzepatide are similar to GLP-1 RAs, which include nausea and vomiting likely caused by the appetite-suppressing mechanism of incretins [47]

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To correct for the impact of switching from study RBCs to non-study RBCs in patients who receive both types of RBCs, an inverse probability censoring weighting method will be used

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Key findings from body composition studies include: Visceral fat (the deep abdominal fat surrounding organs) decreases alongside subcutaneous fat Studies suggest that approximately 60-75% of weight loss comes from fat mass, with the remainder from lean tissue [17] [18] Waist circumferencea proxy measure for abdominal obesitytypically reduces by 6-10 cm on average in clinical trials [8] [9] Improvements in metabolic parameters often occur alongside reductions in visceral fat It is worth noting that individual responses vary considerably

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