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Those with pre-existing chronic liver disease warrant closer surveillance, though semaglutide is not contraindicated in compensated liver disease

Umbrella Review Findings An umbrella review examining magnesium and health outcomes across multiple systematic reviews and meta-analyses found consistent evidence supporting magnesium's role in metabolic health (PMID: 30684032)

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We then incorporated the results from this exercise into the approach outlined in the Munich Re 2025 Life Sciences Report to develop a more refined estimate of future mortality improvement