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In addition, palmitate inhibits the phosphorylation of adenosine 5denosinelation_ENREF_57 protein kinase (AMPK) and blocks autophagy, leading to increased ROS levels in macrophages, which in turn activate the NLRP3 inflammasome and IL-1 secretion (58)

These symptoms are typically mild and temporary, but in some cases, prolonged pain or severe swelling may indicate a more serious reaction

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