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In some circles this route has been regarded as an effective alternative to parenteral administration since the 1950s, during which time several studies showed serum vitamin B12 concentration to normalise after taking large oral doses
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In dermal fibroblasts, GHK-Cu reduces TNF-alpha-induced secretion of IL-6, a major positive regulator of fibrinogen synthesis and inflammatory responses
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A study even showed that taking 500 to 1000 mg of vitamin C daily over 13 weeks could increase glutathione levels by up to 18% in white blood cells and 17% in red blood cells
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